Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pemetrexed. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART known ✓ | P22102 | 9/20 | 0.61 |
| ▸ | DHFR known ✓ | P00374 | 7/20 | 0.61 |
| ▸ | TYMS known ✓ | P04818 | 6/20 | 0.61 |
| ▸ | FOLR1 | P15328 | 4/20 | 0.61 |
| ▸ | SLC46A1 | Q96NT5 | 4/20 | 0.61 |
| ▸ | FOLR2 | P14207 | 3/20 | 0.61 |
| ▸ | SLC19A1 | P41440 | 3/20 | 0.61 |
| ▸ | ATIC | P31939 | 2/20 | 0.61 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.61 |
| ▸ | FRK | P42685 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pemetrexed SCHEMBL208289 | 0.99 | GART (0.62) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL4603766 | 0.99 | GART (0.61) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL16767008 | 0.89 | GART (0.76) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL28552890 | 0.89 | GART (0.76) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL16767007 | 0.89 | GART (0.76) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL19411246 | 0.89 | GART (0.76) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL28545416 | 0.89 | GART (0.76) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL572065 | 0.88 | GART (0.73) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL17394823 | 0.88 | GART (0.75) | GARTDHFRTYMSFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL15569564 | 0.88 | GART (0.75) | GARTDHFRTYMSFOLR1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351755-A1 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF | Chongqing Pharmaceutical Research Institute Co., Ltd. (CN) | 2011-08-03 | — | — | EP | claimed |
| US-20110172424-A1 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF | CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2011-07-14 | — | — | US | claimed |
| CN-101684121-A | New crystal form of pemetrexed diacid and method for preparing same | CHONGQING PHARM RES INST CO | 2010-03-31 | — | — | CN | claimed |
| CN-106478632-B | Novel crystal form of pemetrexed diacid and preparation method thereof | 江苏豪森药业集团有限公司 | 2020-11-27 | — | — | CN | disclosed |
| EP-2351755-B1 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF | CHONGQING PHARM RES INST CO (CN) | 2014-11-12 | — | — | EP | disclosed |
| CN-101684121-B | New crystal form of pemetrexed diacid and method for preparing same | CHONGQING PHARM RES INST CO | 2013-04-03 | — | — | CN | disclosed |
| US-8324382-B2 | Crystalline forms of Pemetrexed diacid, and preparations thereof | CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2012-12-04 | — | — | US | disclosed |
| EP-2351755-A1 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF | Chongqing Pharmaceutical Research Institute Co., Ltd. (CN) | 2011-08-03 | — | — | EP | disclosed |
| US-20110172424-A1 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF | CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2011-07-14 | — | — | US | disclosed |
| CN-101684121-A | New crystal form of pemetrexed diacid and method for preparing same | CHONGQING PHARM RES INST CO | 2010-03-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172424-A1 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF | DCTD, DPYD, TYMP | GART 150/4885DHFR 8/4885TYMS 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.