Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976599 | 1.00 | KCNH2 (0.37) | KCNH2EPHX2POLBLMNACYP3A4 | |
| SCHEMBL21903388 | 1.00 | KCNH2 (0.37) | KCNH2EPHX2POLBLMNACYP3A4 | |
| SCHEMBL21975805 | 0.90 | KCNH2 (0.39) | KCNH2EPHX2POLBCYP3A4CYP2C9 | |
| SCHEMBL21903344 | 0.90 | KCNH2 (0.39) | KCNH2EPHX2POLBCYP3A4CYP2C9 | |
| SCHEMBL21976598 | 0.80 | KCNH2 (0.44) | KCNH2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21975806 | 0.80 | KCNH2 (0.44) | KCNH2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21903367 | 0.80 | KCNH2 (0.44) | KCNH2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21903362 | 0.80 | KCNH2 (0.44) | KCNH2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21903365 | 0.80 | KCNH2 (0.44) | KCNH2LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21903363 | 0.80 | KCNH2 (0.44) | KCNH2LMNACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11072594-B2 | Trioxolane agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-27 | — | — | US | disclosed |
| US-20200140406-A1 | TRIOXOLANE AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072594-B2 | Trioxolane agents | ABCB4, SLC10A1, SLC10A2 | KCNH2 4109/4885EPHX2 203/4885POLB 709/4885 |
| US-20200140406-A1 | TRIOXOLANE AGENTS | ABCB4, SLC10A1, SLC10A2 | KCNH2 4109/4885EPHX2 203/4885POLB 709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.