Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21904151 | 1.00 | CYP19A1 (0.48) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| Lithium Ion SCHEMBL29777174 | 0.87 | CYP19A1 (0.46) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| Lithium Ion SCHEMBL21904364 | 0.87 | CYP19A1 (0.46) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| SCHEMBL21904531 | 0.86 | EPHX2 (0.49) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| SCHEMBL28885642 | 0.86 | EPHX2 (0.49) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| SCHEMBL28885640 | 0.86 | EPHX2 (0.49) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| Hydrochloric Acid SCHEMBL8843403 | 0.80 | EPHX1 (0.53) | CYP19A1MAPTEPHX1ALDH1A1MEN1 | |
| SCHEMBL10528462 | 0.78 | EPHX2 (0.71) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| SCHEMBL10529836 | 0.76 | EPHX2 (0.68) | CYP19A1EPHX2SIGMAR1MAPTEPHX1 | |
| SCHEMBL13096590 | 0.75 | ALDH1A1 (0.51) | EPHX2MAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110769821-B | Spiro indolines as IL-17 modulators | UCB生物制药有限责任公司 | 2023-07-07 | — | — | CN | disclosed |
| US-11052076-B2 | Spirocyclic indolines as IL-17 modulators | UCB Biopharma SRL (BE) | 2021-07-06 | — | — | US | disclosed |
| US-20200138797-A1 | Spirocyclic Indolines as IL-17 Modulators | UCB Biopharma SRL (BE) | 2020-05-07 | — | — | US | disclosed |
| CN-110769821-A | Spirocyclic indolines as IL-17 modulators | UCB生物制药私人有限公司 | 2020-02-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11052076-B2 | Spirocyclic indolines as IL-17 modulators | IL17A, IL2, IL18 | CYP19A1 495/4885EPHX2 3935/4885SIGMAR1 3454/4885 |
| US-20200138797-A1 | Spirocyclic Indolines as IL-17 Modulators | IL17A, IL2, IL18 | CYP19A1 495/4885EPHX2 3935/4885SIGMAR1 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.