IL18 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL11054945	0.79	1/20
SCHEMBL4113028	0.71	1/20
SCHEMBL4113073	0.71	1/20
SCHEMBL11645090	0.71	1/20
SCHEMBL4111010	0.69	1/20
SCHEMBL4121767	0.69	1/20
SCHEMBL11056656	0.69	1/20
SCHEMBL4118174	0.68	1/20
SCHEMBL4116856	0.67	1/20
SCHEMBL4929006	0.67	1/20
SCHEMBL11054936	0.67	1/20
SCHEMBL11896323	0.67	1/20
SCHEMBL11643709	0.66	1/20
SCHEMBL10822517	0.64	1/20
SCHEMBL6125249	0.64	1/20
SCHEMBL11896322	0.63	1/20
SCHEMBL4104728	0.61	1/20
SCHEMBL4118086	0.61	1/20
SCHEMBL7248947	0.61	1/20
SCHEMBL7041250	0.61	1/20

Clinical trials — most relevant to IL18 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effects of Fixed Space Maintainers Luting with Self-Adhesive Resin Cement on the Gingival Crevicular Fluid of Interleukin-18 Level	PHASE4	COMPLETED
Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency As Open Label Extension	PHASE3	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome	EARLY_PHASE1	RECRUITING
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia.	EARLY_PHASE1	UNKNOWN
Minimally Invasive Kidney Transplantation	nan	UNKNOWN
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support	nan	UNKNOWN
Macrolide Mediates Pulmonary Infection of Pseudomonas Aeruginosa	nan	COMPLETED
Corticosteroid Treatment for Acute Respiratory Distress Syndrome	nan	COMPLETED
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF	nan	NOT_YET_RECRUITING
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
IL-10, IL-12 and IL-18 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls	nan	COMPLETED
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.	nan	UNKNOWN
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery	nan	WITHDRAWN
Chromosomal and Morphological Structure of Mature and Immature Male Germ Cells and Recognition of IL-18 in Testicular Tissue of Azoospermic Men	nan	COMPLETED
Tissue and Serum Level of NLRP1, NLRP3 and Il-18 in Early Stages of mf Patients	nan	UNKNOWN
Pigeon Peas (Cajanus Cajan) : a Natural Anti-inflammatory Facilitating Weight Loss in Obese Patients Returning to Sport?	nan	UNKNOWN
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Acupuncture for Reduction of Inflammation	nan	COMPLETED
N/LP Ratio as Predictor of Mortality in Septic AKI Patients	nan	UNKNOWN
The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders	nan	UNKNOWN
The Value of Interleukin-1β and Interleukin-33 Genetic Expression in the Pathogenesis and Differentiation of Primary ITP and SLE-Related Thrombocytopenia	nan	NOT_YET_RECRUITING
Relation of IL23R and IL17A Gene Polymorphisms Plus Serum Levels of IL23 and IL17A to Rheumatoid Arthritis Susceptibility and Activity	nan	NOT_YET_RECRUITING
Ankylosing Spondylitis	nan	NOT_YET_RECRUITING
Decoding the Inflammasome Influence on Treatment Response in Acute Myeloid Leukemia	nan	RECRUITING
Cytokine Status of Covid-19 Patients	nan	COMPLETED
Evaluation of CCR6 Gene Expression and Circulating CCL20 Levels as Potential Biomarkers in Rheumatoid Arthritis	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a IL18 binder may also engage these)

Protein	Name	Similarity
Q9XSR0	—	1.000	Q9XSR0 →
Q5I931	—	1.000	Q5I931 →
Q9TU73	—	1.000	Q9TU73 →
Q95M33	—	1.000	Q95M33 →
Q3ZT29	—	1.000	Q3ZT29 →
P70380	—	1.000	P70380 →
P97636	—	1.000	P97636 →
O19073	—	1.000	O19073 →
Q8QFQ8	—	0.999	Q8QFQ8 →
Q9XSQ7	—	0.998	Q9XSQ7 →
Q2HZH0	—	0.971	Q2HZH0 →
P21621	—	0.969	P21621 →
Q6R2X3	—	0.968	Q6R2X3 →
Q6P5D8	—	0.968	Q6P5D8 →
Q9YGD3	—	0.968	Q9YGD3 →
Q28292	—	0.968	Q28292 →
Q6PUD2	—	0.966	Q6PUD2 →
P14628	—	0.966	P14628 →
P79162	—	0.966	P79162 →
Q28386	—	0.966	Q28386 →
P09428	—	0.966	P09428 →
P41687	—	0.966	P41687 →
Q2MH07	—	0.966	Q2MH07 →
Q8R460	—	0.965	Q8R460 →
P10749	—	0.965	P10749 →
SMCHD1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	0.964	landscape →
P79182	—	0.964	P79182 →
IL36G	Interleukin-36 gamma	0.963	landscape →
IL1B	Interleukin-1 beta	0.963	landscape →
Q9UHA7	—	0.963	Q9UHA7 →