Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.91 |
| ▸ | PDE6C | P51160 | 2/20 | 0.91 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.91 |
| ▸ | PDE1A | P54750 | 1/20 | 0.91 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.91 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL21905134 | 1.00 | PDE5A (0.91) | PDE5APDE6CPDE11APDE1APDE1B | |
| Maleic Acid SCHEMBL21905142 | 1.00 | PDE5A (0.91) | PDE5APDE6CPDE11APDE1APDE1B | |
| Fumaric Acid SCHEMBL21905133 | 1.00 | PDE5A (0.91) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2559771 | 0.95 | PDE5A (1.00) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL29540996 | 0.95 | PDE5A (1.00) | PDE5APDE6CPDE11APDE1APDE1B | |
| Acetic Acid SCHEMBL21905146 | 0.95 | PDE5A (0.95) | PDE5APDE6CPDE11APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL21905136 | 0.95 | PDE5A (0.98) | PDE5APDE6CPDE11APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL21905144 | 0.94 | PDE5A (0.97) | PDE5APDE6CPDE11APDE1APDE1B | |
| Succinic Acid SCHEMBL21905139 | 0.93 | PDE5A (0.92) | PDE5APDE6CPDE11APDE1APDE1B | |
| Succinic Acid SCHEMBL21905140 | 0.93 | PDE5A (0.92) | PDE5APDE6CPDE11APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3650444-B1 | SALT AND POLYMORPH OF BENZOPYRIMIDINONE COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CHINESE ACADEMY OF SCIENCES (CN) | 2022-09-07 | — | — | EP | disclosed |
| EP-3650444-A1 | SALT AND POLYMORPH OF BENZOPYRIMIDINONE COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute Materia Medica, Chinese Academy Of Sciences (CN) | 2020-05-13 | — | — | EP | disclosed |
| US-20200140415-A1 | Salt and Polymorph of Benzopyrimidinone Compound and Pharmaceutical Composition and Use Thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200140415-A1 | Salt and Polymorph of Benzopyrimidinone Compound and Pharmaceutical Composition and Use Thereof | CYP2C19, TPMT, CYP2C9 | PDE5A 292/4885PDE6C 1694/4885PDE11A 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.