Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20975356 | 0.98 | KDM4E (0.43) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL15752593 | 0.84 | NPSR1 (0.44) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL15725241 | 0.83 | NPSR1 (0.43) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL364570 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL10381880 | 0.81 | MEN1 (0.52) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL15709754 | 0.79 | PSMB5 (0.44) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL30106103 | 0.79 | ALDH1A1 (0.41) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL3924027 | 0.79 | ALDH1A1 (0.41) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL15709960 | 0.79 | ALDH1A1 (0.41) | SMN1; SMN2HPGDNPC1TP53POLB | |
| SCHEMBL27860588 | 0.78 | AKR1B1 (0.44) | SMN1; SMN2NPSR1KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10981912-B2 | Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof | GUERBET (FR) | 2021-04-20 | — | — | US | disclosed |
| US-20200123155-A1 | MACROCYCLIC LIGANDS WITH PICOLINATE GROUP(S), COMPLEXES THEREOF AND ALSO MEDICAL USES THEREOF | UNIVERSITE DE BRETAGNE OCCIDENTALE (FR) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981912-B2 | Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof | PYGL, PPIG, PPIB | SMN1; SMN2 3862/4885HPGD 675/4885NPC1 163/4885 |
| US-20200123155-A1 | MACROCYCLIC LIGANDS WITH PICOLINATE GROUP(S), COMPLEXES THEREOF AND ALSO MEDICAL USES THEREOF | PYGL, PPIG, PPIB | SMN1; SMN2 3862/4885HPGD 675/4885NPC1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.