Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30088143 | 1.00 | ALOX5 (0.50) | ALOX5ALDH1A1MEN1KMT2ARXFP1 | |
| SCHEMBL21804941 | 1.00 | ALOX5 (0.50) | ALOX5ALDH1A1MEN1KMT2ARXFP1 | |
| SCHEMBL21804897 | 1.00 | ALOX5 (0.50) | ALOX5ALDH1A1MEN1KMT2ARXFP1 | |
| SCHEMBL31663152 | 0.80 | GAA (0.44) | ALOX5ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL2234874 | 0.80 | GAA (0.44) | ALOX5ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL30797233 | 0.76 | MIF (0.41) | MGLLL3MBTL1 | |
| SCHEMBL19280231 | 0.72 | ALOX5 (0.47) | ALOX5ALDH1A1MEN1KMT2AMGLL | |
| SCHEMBL19996264 | 0.72 | ALOX5 (0.47) | ALOX5ALDH1A1MEN1KMT2AMGLL | |
| SCHEMBL8305787 | 0.71 | GAA (0.46) | ALOX5MEN1KMT2AMGLLMAPT | |
| SCHEMBL16701852 | 0.70 | DDB1 (0.39) | ALDH1A1MEN1KMT2ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |