Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 10/20 | 0.36 |
| ▸ | NPY1R | P25929 | 7/20 | 0.36 |
| ▸ | NPY2R | P49146 | 5/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | GRPR | P30550 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183538 | 0.94 | NPY4R (0.33) | NPY4RNPY1RNPY2RNPY5RDPP4 | |
| SCHEMBL2194721 | 0.93 | BACE1 (0.36) | NPY4RNPY1RNPY2RNPY5RDPP4 | |
| SCHEMBL2159226 | 0.85 | NPY4R (0.50) | NPY4RNPY1RNPY2RNPY5RMC4R | |
| SCHEMBL1650463 | 0.84 | CTSC (0.42) | BACE1GRPR | |
| SCHEMBL29530852 | 0.82 | ERAP2 (0.47) | NPY4RNPY1RNPY2RBACE1 | |
| SCHEMBL29530854 | 0.82 | ERAP2 (0.47) | NPY4RNPY1RNPY2RBACE1 | |
| SCHEMBL30442348 | 0.82 | BACE1 (0.49) | NPY4RNPY1RNPY2RBACE1 | |
| SCHEMBL2194411 | 0.82 | OPRK1 (0.38) | NPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL2181812 | 0.81 | BACE1 (0.34) | BACE1 | |
| SCHEMBL31130605 | 0.81 | ERAP2 (0.48) | NPY4RNPY1RNPY2RBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2019-03-07 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | NPY4R 567/4885NPY1R 544/4885NPY2R 915/4885 |
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | NPY4R 567/4885NPY1R 544/4885NPY2R 915/4885 |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | DNPEP, VIP, PTMS | NPY4R 915/4885NPY1R 631/4885NPY2R 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.