Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | MPL | P40238 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14843891 | 0.79 | MKNK1 (0.49) | MKNK1MKNK2MPLKDR | |
| SCHEMBL28707674 | 0.79 | MKNK1 (0.45) | MKNK1MKNK2MPL | |
| SCHEMBL21925661 | 0.77 | RAD52 (0.54) | — | |
| SCHEMBL25190780 | 0.77 | MEN1 (0.50) | — | |
| SCHEMBL4666187 | 0.77 | RAD52 (0.59) | MKNK1MKNK2MPLKDR | |
| SCHEMBL30611577 | 0.77 | MEN1 (0.56) | MKNK1MKNK2MPL | |
| SCHEMBL23859939 | 0.76 | MKNK1 (0.48) | MKNK1MKNK2MPLKDR | |
| SCHEMBL27711726 | 0.76 | KDM4E (0.49) | KDR | |
| SCHEMBL1323687 | 0.76 | MAPT (0.53) | MKNK1MPLKDR | |
| SCHEMBL29866283 | 0.75 | NPC1 (0.46) | MKNK1MPLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649110-B1 | MYCOBACTERIUM-TUBERCOLOSIS-THIOREDOXIN REDUCTASE INHIBITOR AS ANTITUBERCULOSIS DRUG | UNIV DORTMUND TECH (DE) | 2021-09-08 | — | — | EP | disclosed |
| EP-3649110-A1 | MYOBACTERIUM TUBERCULOSIS-THIOREDOXIN REDUCTASE INHIBITOR AS AN ANTITUBERCULAR AGENT | Technische Universität Dortmund (DE) | 2020-05-13 | — | — | EP | disclosed |