Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21925684 | 0.79 | MKNK1 (0.48) | MKNK1MKNK2MPL | |
| Formic Acid SCHEMBL28707655 | 0.76 | HTR3E (0.51) | MKNK1EGFRJAK2JAK1TYK2 | |
| SCHEMBL28708935 | 0.76 | HTR3E (0.42) | EGFR | |
| SCHEMBL3949696 | 0.74 | HTR3E (0.59) | MKNK1EGFRJAK2JAK1TYK2 | |
| SCHEMBL18786647 | 0.69 | MKNK1 (0.46) | MKNK1MKNK2EGFRJAK2JAK1 | |
| SCHEMBL3241851 | 0.69 | TEK (0.40) | EGFR | |
| SCHEMBL14843891 | 0.69 | MKNK1 (0.49) | MKNK1MKNK2JAK2JAK1TYK2 | |
| SCHEMBL4630887 | 0.68 | GSK3A (0.53) | MKNK1MKNK2JAK2JAK1TYK2 | |
| SCHEMBL16916919 | 0.67 | JAK2 (0.52) | MKNK1MKNK2EGFRJAK2JAK1 | |
| SCHEMBL18786850 | 0.67 | MKNK1 (0.66) | MKNK1MKNK2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114044774-B | EGFR inhibitor and preparation method and application thereof | 光武惠文生物科技(北京)有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-114044774-A | EGFR inhibitor and preparation method and application thereof | 北京超维知药科技有限公司 | 2022-02-15 | — | — | CN | disclosed |