Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22971333 | 0.77 | KDR (0.44) | KDM4ERAB9ANPC1KMT2ABRAF | |
| SCHEMBL25190780 | 0.77 | MEN1 (0.50) | KDM4ERAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL29806164 | 0.77 | RAD52 (0.53) | KDM4ERAB9ANPC1KMT2APOLB | |
| SCHEMBL28324147 | 0.77 | KMT2A (0.61) | KDM4ERAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL31220873 | 0.77 | RAB9A (0.61) | KDM4ERAB9ANPC1KMT2APOLB | |
| SCHEMBL15145230 | 0.77 | AURKA (0.56) | KDM4ERAB9ANPC1KMT2APOLB | |
| SCHEMBL21925684 | 0.76 | MKNK1 (0.48) | KDR | |
| SCHEMBL2735066 | 0.76 | MEN1 (0.55) | KDM4ERAB9ANPC1KMT2APOLB | |
| SCHEMBL4874678 | 0.75 | AURKA (0.60) | KDM4ERAB9ANPC1KMT2ACASP1 | |
| SCHEMBL28770707 | 0.74 | ALDH1A1 (0.47) | KDM4ERAB9ANPC1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101111483-B | IGF-1R inhibitors | KYOWA HAKKO KIRIN CO.,LTD. (JP) | 2011-12-14 | — | — | CN | disclosed |
| CN-101111483-A | IGF-1R inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2008-01-23 | — | — | CN | disclosed |