Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16914260 | 0.84 | USP30 (0.43) | USP2SMN1; SMN2USP30TSHRALOX15 | |
| SCHEMBL22720245 | 0.81 | USP2 (0.40) | USP2SMN1; SMN2USP30TSHRALOX15 | |
| SCHEMBL16914261 | 0.77 | USP30 (0.44) | USP2SMN1; SMN2USP30TSHRALOX15 | |
| SCHEMBL29347028 | 0.76 | USP30 (0.46) | USP2SMN1; SMN2USP30HDAC1HDAC8 | |
| SCHEMBL30577842 | 0.75 | CHRM2 (0.35) | USP2SMN1; SMN2USP30TSHRALOX15 | |
| SCHEMBL24089120 | 0.74 | USP2 (0.50) | USP2SMN1; SMN2USP30TSHRALOX15 | |
| SCHEMBL30842433 | 0.74 | USP2 (0.50) | USP2SMN1; SMN2TSHRALOX15ATM | |
| SCHEMBL31645855 | 0.74 | GPR119 (0.41) | USP2SMN1; SMN2TSHRALOX15ATM | |
| SCHEMBL23901933 | 0.74 | USP30 (0.42) | USP2SMN1; SMN2USP30TSHRALOX15 | |
| SCHEMBL27354197 | 0.72 | NR1H2 (0.41) | USP2SMN1; SMN2USP30ATMGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310774-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2020-04-29 | — | — | EP | disclosed |