Sugi Predict

Sugi Predict / Compounds / SCHEMBL2192956

SCHEMBL2192956

SCHEMBL2192956

Cn1c(-c2ccccc2)c(-c2ccccc2)n(Cc2ccccc2)c1=[Pt].IN(I)C1CCCCC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 1/20 0.35
▸ DRD4 P21917 1/20 0.35
▸ DRD3 P35462 1/20 0.35
▸ KMT2A Q03164 4/20 0.35
▸ HSD17B10 Q99714 2/20 0.34
▸ USP2 O75604 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ TSHR P16473 2/20 0.34
▸ TP53 P04637 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ MEN1 O00255 3/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ PTAFR P25105 2/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ CHRM1 P11229 1/20 0.34
▸ HRH1 P35367 1/20 0.34
▸ POLB P06746 1/20 0.33
▸ RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2194479 0.86 ALDH1A1 (0.38) KMT2AHSD17B10USP2HPGDTSHR
SCHEMBL2192492 0.86 ALDH1A1 (0.38) KMT2AHSD17B10USP2HPGDTSHR
SCHEMBL2195495 0.85 ALDH1A1 (0.36) DRD2KMT2AHSD17B10HPGDTSHR
SCHEMBL2194997 0.84 ALDH1A1 (0.34) HSD17B10HPGDTSHRMAPK1KDM4E
SCHEMBL2193600 0.81 DRD2 (0.35) DRD2DRD4DRD3KMT2AHSD17B10
SCHEMBL2195591 0.81 DRD2 (0.35) DRD2DRD4DRD3KMT2AHSD17B10
SCHEMBL2196175 0.79 TSHR (0.35) DRD2DRD4DRD3HSD17B10HPGD
SCHEMBL2196569 0.79 DRD2 (0.36) DRD2DRD4DRD3KMT2AHSD17B10
SCHEMBL2192700 0.78 DRD2 (0.37) DRD2DRD4DRD3RAB9APDE5A
SCHEMBL2197224 0.76 ALDH1A1 (0.38) KMT2AHSD17B10USP2HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8980875-B2 Platinum-N-heterocyclic carbene derivatives, preparation thereof and therapeutic use thereof CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2015-03-17 — — US disclosed
US-20130338128-A1 PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2013-12-19 — — US disclosed
US-8481522-B2 Platinum-N-heterocyclic carbene derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2013-07-09 — — US disclosed
US-20110172199-A1 PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-07-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130338128-A1 PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SCO2, C3AR1, IDH1 DRD2 504/4885DRD4 434/4885DRD3 121/4885
US-20110172199-A1 PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SCO2, C3AR1, IDH1 DRD2 504/4885DRD4 434/4885DRD3 121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.