Sugi Predict

Sugi Predict / Compounds / SCHEMBL2193153

SCHEMBL2193153

SCHEMBL2193153

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C]=O)CO

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ENPEP Q07075 6/20 0.40
▸ BMP1 P13497 3/20 0.37
▸ ALDH1A1 P00352 1/20 0.35
▸ DPP4 P27487 1/20 0.35
▸ DPP8 Q6V1X1 1/20 0.35
▸ DPP9 Q86TI2 1/20 0.35
▸ NAALAD2 Q9Y3Q0 1/20 0.35
▸ TASP1 Q9H6P5 1/20 0.34
▸ GABRP O00591 2/20 0.34
▸ GABRD O14764 2/20 0.34
▸ GABRA1 P14867 2/20 0.34
▸ GABRB1 P18505 2/20 0.34
▸ GABRG2 P18507 2/20 0.34
▸ GABRB3 P28472 2/20 0.34
▸ GABRA5 P31644 2/20 0.34
▸ GABRA3 P34903 2/20 0.34
▸ GABRA2 P47869 2/20 0.34
▸ GABRB2 P47870 2/20 0.34
▸ GABRA4 P48169 2/20 0.34
▸ GABRE P78334 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2197432 0.88 BMP1 (0.42) ENPEPBMP1DPP4DPP8DPP9
SCHEMBL2196455 0.86 ENPEP (0.42) ENPEPBMP1ALDH1A1DPP4DPP8
SCHEMBL11347512 0.86 ENPEP (0.43) ENPEPALDH1A1DPP4DPP8DPP9
SCHEMBL2195663 0.84 BACE1 (0.41) ENPEPBMP1TASP1
SCHEMBL29886827 0.84 ENPEP (0.47) ENPEPNAALAD2TASP1FOLH1
SCHEMBL11472810 0.82 ENPEP (0.43) ENPEPBMP1DPP4DPP8DPP9
SCHEMBL2182215 0.82 DPP4 (0.46) ENPEPBMP1DPP4DPP8DPP9
SCHEMBL12496189 0.80 ENPEP (0.53) ENPEPNAALAD2GABRPGABRDGABRA1
SCHEMBL7822201 0.80 ENPEP (0.53) ENPEPNAALAD2GABRPGABRDGABRA1
SCHEMBL12496193 0.80 ENPEP (0.53) ENPEPNAALAD2GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190070251-A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES NEKTAR THERAPEUTICS 2019-03-07 — — US disclosed
US-9682153-B2 Polymer conjugates of therapeutic peptides NEKTAR THERAPEUTICS (US) 2017-06-20 — — US disclosed
US-20160022828-A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES NEKTAR THERAPEUTICS 2016-01-28 — — US disclosed
US-20110171312-A1 MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE NEKTAR THERAPEUTICS (US) 2011-07-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160022828-A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES NGLY1, CD44, IAPP ENPEP 19/4885BMP1 3740/4885ALDH1A1 3923/4885
US-20190070251-A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES NGLY1, CD44, IAPP ENPEP 19/4885BMP1 3740/4885ALDH1A1 3923/4885
US-20110171312-A1 MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE DNPEP, VIP, PTMS ENPEP 13/4885BMP1 1697/4885ALDH1A1 4177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.