Sugi Predict

Sugi Predict / Compounds / SCHEMBL21932895

SCHEMBL21932895

SCHEMBL21932895

CC(C)(C)OC(=O)CCC(C(N)=O)N1Cc2c(Br)cccc2C1=O

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ MAPT P10636 2/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ SDCBP O00560 1/20 0.32
▸ SDC2 P34741 1/20 0.32
▸ VHL P40337 1/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ UCHL1 P09936 1/20 0.32
▸ PTPRC P08575 2/20 0.31
▸ THRB P10828 2/20 0.31
▸ LMNA P02545 1/20 0.31
▸ CBLB Q13191 1/20 0.31
▸ POLB P06746 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20076133 1.00 ALOX15 (0.35) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL29493294 0.89 ALOX15 (0.34) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL29546840 0.89 ALOX15 (0.34) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL2255636 0.89 ALOX15 (0.34) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL15467376 0.89 ALOX15 (0.34) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL17724288 0.89 ALOX15 (0.34) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL17724339 0.89 ALOX15 (0.34) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL18666553 0.89 NPC1 (0.39) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL29471940 0.89 NPC1 (0.39) ALOX15KDM4EMAPTSMN1; SMN2NPC1
SCHEMBL18639820 0.89 NPC1 (0.39) ALOX15KDM4EMAPTSMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024130095-A9 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-08-02 — — WO disclosed
WO-2024130095-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-06-20 — — WO disclosed
US-20230159573-A1 SMALL MOLECULE STAT PROTEIN DEGRADERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-05-25 — — US disclosed
US-20220298172-A1 PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS BIOTHERYX, INC. (US) 2022-09-22 — — US disclosed
US-11352338-B2 Substituted isoindolinones BIOTHERYX, INC. (US) 2022-06-07 — — US disclosed
US-11345712-B2 Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications BIOTHERYX, INC. (US) 2022-05-31 — — US disclosed
CN-114502543-A Targeted protein compounds, pharmaceutical compositions and therapeutic applications thereof 拜欧斯瑞克斯公司 2022-05-13 — — CN disclosed
EP-3976623-A1 COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS Biotheryx, Inc. (US) 2022-04-06 — — EP disclosed
EP-3880669-A1 SUBSTITUTED ISOINDOLINONES Biotheryx, Inc. (US) 2021-09-22 — — EP disclosed
CN-113423701-A Substituted isoindolinones 拜欧斯瑞克斯公司 2021-09-21 — — CN disclosed
WO-2020242960-A1 COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS BIOTHERYX, INC. (US) 2020-12-03 — — WO disclosed
US-20200369679-A1 PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS BIOTHERYX, INC. 2020-11-26 — — US disclosed
US-10844039-B2 Substituted isoindolinones BIOTHERYX, INC. (US) 2020-11-24 — — US disclosed
US-20200325114-A1 SUBSTITUTED ISOINDOLINONES BIOTHERYX, INC. (US) 2020-10-15 — — US disclosed
WO-2020102195-A1 SUBSTITUTED ISOINDOLINONES BIOTHERYX, INC. (US) 2020-05-22 — — WO disclosed
US-20200148663-A1 SUBSTITUTED ISOINDOLINONES BIOTHERYX, INC. 2020-05-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200148663-A1 SUBSTITUTED ISOINDOLINONES BRCA1, FANCI, GOT2 ALOX15 2369/4885KDM4E 4258/4885MAPT 1804/4885
US-20220298172-A1 PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS HSP90B1, EIF4EBP1, SERPINA6 ALOX15 3782/4885KDM4E 4181/4885MAPT 668/4885
US-10844039-B2 Substituted isoindolinones BRCA1, FANCI, GOT2 ALOX15 2369/4885KDM4E 4258/4885MAPT 1804/4885
US-11345712-B2 Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications HSP90B1, EIF4EBP1, SERPINA6 ALOX15 3782/4885KDM4E 4181/4885MAPT 668/4885
US-20200325114-A1 SUBSTITUTED ISOINDOLINONES BRCA1, FANCI, GOT2 ALOX15 2369/4885KDM4E 4258/4885MAPT 1804/4885
US-20200369679-A1 PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS HSP90B1, EIF4EBP1, SERPINA6 ALOX15 3782/4885KDM4E 4181/4885MAPT 668/4885
US-20230159573-A1 SMALL MOLECULE STAT PROTEIN DEGRADERS STAT1, STAT3, STAT5A ALOX15 4771/4885KDM4E 672/4885MAPT 2602/4885
US-11352338-B2 Substituted isoindolinones BRCA1, FANCI, GOT2 ALOX15 2369/4885KDM4E 4258/4885MAPT 1804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.