Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721526 | 1.00 | PRMT5 (0.44) | PRMT5WDR77HPGDKMT2AALDH1A1 | |
| SCHEMBL29391782 | 1.00 | PRMT5 (0.44) | PRMT5WDR77HPGDKMT2AALDH1A1 | |
| SCHEMBL20721403 | 0.88 | PRMT5 (0.43) | PRMT5WDR77SLC22A12 | |
| SCHEMBL29391767 | 0.88 | PRMT5 (0.43) | PRMT5WDR77SLC22A12 | |
| SCHEMBL20721455 | 0.88 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL20723397 | 0.83 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL29391758 | 0.83 | PRMT5 (0.58) | PRMT5WDR77HPGDKMT2AALDH1A1 | |
| SCHEMBL20721601 | 0.83 | PRMT5 (0.58) | PRMT5WDR77HPGDKMT2AALDH1A1 | |
| SCHEMBL20721499 | 0.82 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL23897087 | 0.81 | PRMT5 (0.46) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078205-B2 | Selective inhibitors of protein arginine methlytransferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-08-03 | — | — | US | disclosed |
| US-20200148692-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078205-B2 | Selective inhibitors of protein arginine methlytransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 142/4885HPGD 1877/4885 |
| US-20200148692-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 283/4885HPGD 1803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.