Known targets — ChEMBL curated mechanism
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
The experimentally established mechanism targets of Acadesine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.77 |
| ▸ | FBP1 | P09467 | 1/20 | 0.69 |
| ▸ | ATIC | P31939 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | THPO | P40225 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acadesine SCHEMBL7141001 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL28745421 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL2619704 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL2394079 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL10017743 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL6113798 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL5053863 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL14520658 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL2631614 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL8722270 | 0.95 | KDM4E (0.91) | KDM4ETP53TDP1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3477 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144879-A1 | ANTI-VIRAL AND HEPATIC-TARGETED DRUGS | AI-BIOPHARMA (FR) | 2026-05-28 | — | — | US | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| US-12625139-B2 | Methods for modulation of acetyltransferase activity and applications thereof including treatments | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2026-05-12 | — | — | US | claimed |
| US-20260097105-A1 | SYSTEMS, FORMULATIONS AND METHODS FOR GENERATING UNIVERSAL PEPTIDE/MHC COMPLEXES WITH ENGINEERED DISULFIDE CONNECTING THE HEAVY AND LIGHT CHAINS | CHILDRENS HOSPITAL PHILADELPHIA (US) | 2026-04-09 | — | — | US | claimed |
| WO-2026042726-A1 | EMBRYO ACQUISITION METHOD | 学校法人金沢医科大学 | 2026-02-26 | — | — | WO | claimed |
| US-20260041336-A1 | PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK | NEW YORK UNIVERSITY (US) | 2026-02-12 | — | — | US | claimed |
| US-20260034158-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM COMPRISING 5-ETHYNYL-2'-DEOXYURIDINE | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2026-02-05 | — | — | US | claimed |
| EP-4652841-A1 | SUBSTANCE (HATCHING ACCELERATOR) ACCELERATING HATCHING OF CYST NEMATODES | Hirotsu Bio Science Inc. (JP) | 2025-11-26 | — | — | EP | claimed |
| US-20250345296-A1 | COMPOSITIONS AND METHODS FOR THE MODULATION OF MITOPHAGY FOR USE IN TREATMENT OF MITOCHONDRIAL DISEASE | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2025-11-13 | — | — | US | claimed |
| US-20250325501-A1 | A SPHINGOSINE-1-PHOSPHATE RECEPTOR (S1PR) MODULATOR FOR USE IN TREATING A PATIENT SUFFERING FROM ALZHEIMER'S DEMENTIA | UNIV OTTO VON GUERICKE MAGDEBURG (DE) | 2025-10-23 | — | — | US | claimed |
| EP-0427799-B1 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | GENSIA PHARMA (US) | 1994-11-30 | — | — | EP | claimed |
| WO-1994013324-A1 | LIPID PRODRUGS FOR ORAL ADMINISTRATION | VESTAR, INC. (US) | 1994-06-23 | — | — | WO | claimed |
| US-5030623-A | Administering a purine nucleoside compound or analog; antiallergenic | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1991-07-09 | — | — | US | claimed |
| US-4912092-A | Prevent tissue damage; administering purine nucleoside | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1990-03-27 | — | — | US | claimed |
| EP-0262125-A4 | AICA riboside for the prophylactic treatment of diseases with restricted blood flow. | GRUBER HARRY EDWARD | 1989-07-26 | — | — | EP | claimed |
| EP-0262125-A1 | AICA riboside for the prophylactic treatment of diseases with restricted blood flow. | GRUBER HARRY EDWARD | 1988-04-06 | — | — | EP | claimed |
| WO-1987005807-A1 | A METHOD OF INCREASING ADENOSINE EXCRETION | GRUBER HARRY EDWARD | 1987-10-08 | — | — | WO | claimed |
| US-4293690-A | PROTECTING HYDROXYLS OF 5-AMINO-1-B-D-RIBOFURANOSYLIMIDAZOLE-4-CARBOXAMIDE, DEHYDRATION, CYCLIZATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-10-06 | — | — | US | claimed |
| US-4255565-A | REACTION OF 5-AMINO-1-B-D-RIBOFURANOSYL-4-CYANOIMIDAZOLE AND AN N-CARBO-SUBSTITUTED CYANAMIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-03-10 | — | — | US | claimed |
| EP-0017465-A1 | Production of 2,6-diaminonebularines | Takeda Chemical Industries, Ltd. (JP) | 1980-10-15 | — | — | EP | claimed |