Known targets — ChEMBL curated mechanism
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
The experimentally established mechanism targets of Acadesine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.77 |
| ▸ | FBP1 | P09467 | 1/20 | 0.69 |
| ▸ | ATIC | P31939 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | THPO | P40225 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acadesine SCHEMBL219336 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL7141001 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL28745421 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL2619704 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL2394079 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL10017743 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL6113798 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL5053863 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL14520658 | 1.00 | KDM4E (1.00) | KDM4ETP53TDP1MAPTSMN1; SMN2 | |
| Acadesine SCHEMBL8722270 | 0.95 | KDM4E (0.91) | KDM4ETP53TDP1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10842806-B2 | Methods for treating ocular inflammatory disorders | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20180036329-A1 | METHODS FOR TREATING OCULAR INFLAMMATORY DISORDERS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2018-02-08 | — | — | US | disclosed |
| US-20120264605-A1 | Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2012-10-18 | — | — | US | disclosed |
| US-8232265-B2 | Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2012-07-31 | — | — | US | disclosed |
| US-20120094948-A1 | Analogous Compounds of 6-Thioguanosine Triphosphate, their use in Medical Fields and Processes for their Preparation | GIULIANI INTERNATIONAL LIMITED | 2012-04-19 | — | — | US | disclosed |
| US-8114986-B2 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INTERNATIONAL LIMITED (IE) | 2012-02-14 | — | — | US | disclosed |
| US-8093380-B2 | Viricides, antitumor agents, anticancer agents | PHARMASSET, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100323980-A9 | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | NOGRA PHARMA LIMITED (IE) | 2010-12-23 | — | — | US | disclosed |
| US-20090258837-A1 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INTERNATIONAL LIMITED (IE) | 2009-10-15 | — | — | US | disclosed |
| WO-2009019600-A2 | MODULATION OF ENDOGENOUS AMPK LEVELS FOR THE TREATMENT OF OBESITY | DR. REDDY'S LABORATORIES LTD. (US) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264605-A1 | Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients | SLC5A6, PNLIP, IPMK | KDM4E 4586/4885TP53 395/4885TDP1 1258/4885 |
| US-10842806-B2 | Methods for treating ocular inflammatory disorders | ATF4, AMPD1, ATF1 | KDM4E 3330/4885TP53 4573/4885TDP1 3280/4885 |
| US-20090258837-A1 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | TPMT, MTAP, G6PD | KDM4E 1421/4885TP53 2809/4885TDP1 2789/4885 |
| US-20180036329-A1 | METHODS FOR TREATING OCULAR INFLAMMATORY DISORDERS | ATF4, AMPD1, ATF1 | KDM4E 3330/4885TP53 4573/4885TDP1 3280/4885 |
| US-20120094948-A1 | Analogous Compounds of 6-Thioguanosine Triphosphate, their use in Medical Fields and Processes for their Preparation | TPMT, MTAP, G6PD | KDM4E 1421/4885TP53 2809/4885TDP1 2789/4885 |
| US-20100323980-A9 | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | TPMT, G6PD, MTAP | KDM4E 1255/4885TP53 3205/4885TDP1 2876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.