Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17626254 | 0.82 | PORCN (0.64) | THRBKMT2APORCNMAPTRXFP1 | |
| SCHEMBL20161605 | 0.80 | POLB (0.65) | THRBKMT2APORCNMAPTRXFP1 | |
| SCHEMBL19036549 | 0.79 | KMT2A (0.63) | THRBKMT2APORCNMAPTRXFP1 | |
| SCHEMBL18166581 | 0.71 | RXFP1 (0.67) | THRBKMT2ARXFP1CYP1A2POLB | |
| SCHEMBL18166643 | 0.71 | RXFP1 (0.72) | THRBKMT2APORCNMAPTRXFP1 | |
| SCHEMBL10113920 | 0.70 | PORCN (0.70) | THRBKMT2APORCNMAPTRXFP1 | |
| SCHEMBL20161625 | 0.70 | THRB (0.67) | THRBKMT2ARXFP1CYP1A2POLB | |
| SCHEMBL18166677 | 0.70 | RXFP1 (0.70) | THRBKMT2APORCNMAPTRXFP1 | |
| SCHEMBL20161686 | 0.70 | THRB (0.78) | THRBKMT2APORCNRXFP1CYP1A2 | |
| SCHEMBL15375895 | 0.70 | KMT2A (0.74) | THRBKMT2ARXFP1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999699-B1 | PURINE DIONES AS WNT PATHWAY MODULATORS | AGENCY SCIENCE TECH & RES (SG) | 2020-04-29 | — | — | EP | disclosed |