Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618341 | 0.79 | DYRK1A (0.46) | DYRK1AMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL126525 | 0.79 | DYRK1A (0.46) | DYRK1AMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL25768673 | 0.75 | DYRK1A (0.35) | DYRK1AMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL21333142 | 0.75 | DYRK1A (0.35) | DYRK1AMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL30848471 | 0.75 | DYRK1A (0.35) | DYRK1AMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL15435737 | 0.75 | DYRK1A (0.39) | DYRK1AMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL25173870 | 0.75 | DYRK1A (0.36) | DYRK1A | |
| SCHEMBL23666903 | 0.73 | MAP4K1 (0.35) | — | |
| SCHEMBL15469468 | 0.73 | MAOB (0.38) | DYRK1AMAPTRAB9ANPC1POLB | |
| SCHEMBL19844887 | 0.72 | ITGB2 (0.37) | MAPTPKMRAB9ASMN1; SMN2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020083377-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-04-30 | — | — | WO | disclosed |