Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126525 | 1.00 | DYRK1A (0.46) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL21935993 | 0.79 | DYRK1A (0.35) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL15435737 | 0.75 | DYRK1A (0.39) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL30848471 | 0.75 | DYRK1A (0.35) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL21333142 | 0.75 | DYRK1A (0.35) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL25768673 | 0.75 | DYRK1A (0.35) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL8103788 | 0.75 | DYRK1A (0.36) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL30540459 | 0.73 | MAP3K14 (0.55) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL23649681 | 0.73 | MAP4K1 (0.38) | DYRK1AMAPTALDH1A1GAANOS2 | |
| SCHEMBL30042104 | 0.73 | MAP4K1 (0.38) | DYRK1AMAPTALDH1A1GAANOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |