Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21936057 | 0.88 | MAPT (0.46) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL31528481 | 0.87 | RAB9A (0.52) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL20876119 | 0.86 | PTGS1 (0.44) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL21937178 | 0.84 | PTGS1 (0.42) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL21936310 | 0.83 | PTGDR2 (0.38) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL20876131 | 0.83 | PTGS1 (0.41) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL20876163 | 0.83 | PTGS1 (0.41) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL8193697 | 0.80 | TARBP2 (0.46) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL31646921 | 0.79 | ELANE (0.45) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL1445392 | 0.77 | NPC1 (0.56) | PTGS1PTGS2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601745-B | Azaaryl amide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112601745-A | Azaaryl amide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2021-04-02 | — | — | CN | disclosed |
| WO-2020082921-A1 | NITROGEN HETEROARYL AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2020-04-30 | — | — | WO | disclosed |