Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21938844 | 0.89 | OPRK1 (0.39) | HRH4S1PR1NPC1RAB9AGAA | |
| SCHEMBL21938898 | 0.86 | HRH4 (0.41) | HRH4NPC1RAB9AMAPTKDM4E | |
| SCHEMBL21939007 | 0.80 | ACHE (0.51) | HRH4NPC1RAB9AMAPTKDM4E | |
| SCHEMBL21938848 | 0.78 | HRH4 (0.41) | HRH4S1PR1RAB9AMAPTKDM4E | |
| SCHEMBL21939249 | 0.78 | USP7 (0.54) | KMT2A | |
| SCHEMBL21939277 | 0.76 | OPRK1 (0.47) | S1PR1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL21938889 | 0.76 | KCNH2 (0.41) | NPC1RAB9A | |
| SCHEMBL21939030 | 0.75 | ALOX5AP (0.42) | HRH4NPC1RAB9AMAPTKDM4E | |
| SCHEMBL21939240 | 0.74 | ACHE (0.59) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL21939024 | 0.70 | PIK3CA (0.47) | HRH4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081682-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |