Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 5/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940294 | 0.78 | LRRK2 (0.44) | LRRK2STK3STK26FFAR2 | |
| SCHEMBL21940791 | 0.78 | LRRK2 (0.44) | LRRK2STK3STK26FFAR2 | |
| SCHEMBL21940812 | 0.72 | FFAR2 (0.38) | FFAR2 | |
| SCHEMBL21940810 | 0.72 | LRRK2 (0.41) | LRRK2ADORA2AADORA1 | |
| SCHEMBL23622932 | 0.69 | LRRK2 (0.46) | LRRK2STK3STK26FFAR2 | |
| SCHEMBL29173621 | 0.69 | LRRK2 (0.43) | LRRK2STK3STK26FFAR2 | |
| SCHEMBL13724161 | 0.69 | LRRK2 (0.46) | LRRK2STK3STK26FFAR2 | |
| SCHEMBL30205934 | 0.69 | LRRK2 (0.43) | LRRK2STK3STK26FFAR2 | |
| SCHEMBL21940805 | 0.69 | ELOVL1 (0.39) | FFAR2 | |
| SCHEMBL21940807 | 0.69 | LRRK2 (0.44) | LRRK2STK3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |