SCHEMBL21940469

SCHEMBL21940469

Nc1cc(OCC2(C(F)(F)F)CC2)nc(C(F)(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
MBOAT4 Q96T53 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
SCN9A Q15858 2/20 0.32
LOXL2 Q9Y4K0 3/20 0.32
KDM4E B2RXH2 1/20 0.31
LOX P28300 1/20 0.30
CA2 P00918 1/20 0.30
CHKA P35790 1/20 0.30
TSHR P16473 1/20 0.30
FSHR P23945 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20606883 0.77 HSP90AA1 (0.42) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL21940793 0.74 NUDT1 (0.41) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL21940467 0.73 IDH1 (0.36) HSP90AA1HSP90AB1MBOAT4ALDH1A1MAPT
SCHEMBL20606902 0.73 HSP90AA1 (0.39) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL21941067 0.73 TLR7 (0.39) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL21940590 0.72 IDH1 (0.37) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL20606989 0.72 HSP90AA1 (0.38) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL20242647 0.72 TLR7 (0.43) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2
SCHEMBL24760476 0.71 GAA (0.46) HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E
SCHEMBL8788157 0.68 HSP90AA1 (0.52) HSP90AA1HSP90AB1ALDH1A1MAPTLOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3423445-B1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS GALAPAGOS NV (BE) 2020-04-01 EP disclosed