Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940590 | 0.85 | IDH1 (0.37) | IDH1HSP90AA1HSP90AB1LOXL2FFAR2 | |
| SCHEMBL20606883 | 0.76 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1LOXL2ALDH1A1MAPT | |
| SCHEMBL20606969 | 0.75 | CA2 (0.39) | LOXL2 | |
| SCHEMBL21940313 | 0.74 | MCHR1 (0.43) | LOXL2SCN8A | |
| SCHEMBL21940469 | 0.73 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1LOXL2MBOAT4ALDH1A1 | |
| SCHEMBL21940793 | 0.73 | NUDT1 (0.41) | HSP90AA1HSP90AB1LOXL2ALDH1A1MAPT | |
| SCHEMBL21940508 | 0.73 | GPR84 (0.41) | — | |
| SCHEMBL21941067 | 0.72 | TLR7 (0.39) | HSP90AA1HSP90AB1LOXL2ALDH1A1MAPT | |
| SCHEMBL20606902 | 0.72 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1LOXL2ALDH1A1MAPT | |
| SCHEMBL20606989 | 0.71 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1LOXL2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |