Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 13/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828287 | 0.74 | PDE2A (0.57) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2191629 | 0.68 | PDE2A (0.49) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL55774 | 0.67 | PDE2A (0.64) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL24393156 | 0.66 | PDE2A (0.62) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30095667 | 0.65 | PDE2A (0.60) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL130521 | 0.65 | PDE2A (0.60) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29685062 | 0.65 | PDE2A (0.60) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2195963 | 0.64 | PDE2A (0.46) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29931542 | 0.63 | KMT2A (0.49) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4061100 | 0.63 | KMT2A (0.78) | PDE2AKMT2ACYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172216-A1 | PYRAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172216-A1 | PYRAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, PI4KA | PDE2A 2052/4885KMT2A 3692/4885CYP1A2 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.