Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 13/20 | 0.60 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130521 | 1.00 | PDE2A (0.60) | PDE2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL55774 | 0.81 | PDE2A (0.64) | PDE2AKMT2AGAACYP1A2CYP3A4 | |
| SCHEMBL130702 | 0.81 | PI4KA (0.56) | PDE2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL24393156 | 0.79 | PDE2A (0.62) | PDE2AKMT2AGAACYP1A2CYP3A4 | |
| SCHEMBL4409891 | 0.79 | PI4KA (0.55) | PDE2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL130798 | 0.78 | PI4KA (0.53) | PDE2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL128577 | 0.78 | PI4KA (0.53) | PDE2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL21481725 | 0.78 | HTT (0.39) | PDE2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30095667 | 0.78 | PDE2A (0.60) | PDE2AKMT2AGAACYP1A2CYP3A4 | |
| SCHEMBL24500179 | 0.77 | KDM4E (0.41) | PDE2API4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114667282-B | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| WO-2023244430-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | ALPHALA CO., LTD. (TW) | 2023-12-21 | — | — | WO | disclosed |
| EP-4048656-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | Alphala Co., Ltd. (TW) | 2022-08-31 | — | — | EP | disclosed |
| CN-114667282-A | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2022-06-24 | — | — | CN | disclosed |