Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | PDE2A | O00408 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950710 | 0.83 | HTR2C (0.63) | KMT2AHTR2CTP53KDM4EMAPT | |
| SCHEMBL13943308 | 0.82 | HTR2C (0.76) | KMT2AHTR2CTP53KDM4EMAPT | |
| SCHEMBL4057912 | 0.81 | KMT2A (0.64) | KMT2AHTR2CTP53KDM4EMAPT | |
| SCHEMBL20558376 | 0.80 | TP53 (0.52) | KMT2AHTR2CTP53KDM4EMAPT | |
| SCHEMBL3949781 | 0.80 | HTR2C (0.66) | KMT2AHTR2CTP53KDM4EMAPT | |
| SCHEMBL13087256 | 0.80 | GAA (0.78) | KMT2AHTR2CPDE2AKDM4EMAPT | |
| SCHEMBL4063948 | 0.79 | KMT2A (0.65) | KMT2AHTR2CTP53PDE2AKDM4E | |
| SCHEMBL13943325 | 0.79 | HTR2C (0.65) | KMT2AHTR2CTP53 | |
| SCHEMBL13943255 | 0.78 | SHMT2 (0.65) | KMT2AHTR2CTP53KDM4EMAPT | |
| SCHEMBL22806016 | 0.78 | GAA (0.80) | KMT2AHTR2CPDE2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |