SCHEMBL21942706

SCHEMBL21942706

Nc1nc2c(ncn2[C@@H]2OC(CO[PH](=O)O)[C@@H](O)[C@H]2OP(=O)(O)OCC2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c(=O)[nH]1

nearest known ligand 0.72

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ RNASEL Q05823 13/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21943164 1.00 RNASEL (0.72) RNASEL
SCHEMBL23776041 0.97 RNASEL (0.66) RNASEL
SCHEMBL21943266 0.95 RNASEL (0.65) RNASEL
SCHEMBL27275674 0.95 RNASEL (0.65) RNASEL
SCHEMBL27273300 0.95 RNASEL (0.64) RNASEL
SCHEMBL27273288 0.95 RNASEL (0.64) RNASEL
SCHEMBL21942787 0.94 RNASEL (0.63) RNASEL
SCHEMBL23776034 0.94 RNASEL (0.63) RNASEL
SCHEMBL24499599 0.94 RNASEL (0.63) RNASEL
SCHEMBL18521686 0.94 RNASEL (0.63) RNASEL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200113924-A1 CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT MERCK SHARP & DOHME CORP. (US) 2020-04-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200113924-A1 CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT STING1, CGAS, MAVS RNASEL 3382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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