Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31520397 | 0.86 | DPP4 (0.51) | DPP4ENPEPPDCD1LG2CD274 | |
| SCHEMBL31181198 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MAPTPTGS1DPP4MME | |
| SCHEMBL30308707 | 0.80 | CTSC (0.31) | ALDH1A1MAPTPTGS1ENPEP | |
| SCHEMBL30684497 | 0.77 | DPP4 (0.47) | DPP4ENPEPPDCD1LG2CD274MME | |
| SCHEMBL26263797 | 0.77 | DPP4 (0.47) | DPP4ENPEPPDCD1LG2CD274MME | |
| SCHEMBL29378743 | 0.77 | CD274 (0.52) | ALDH1A1MAPTPTGS1ENPEPPDCD1LG2 | |
| SCHEMBL30658172 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTPTGS1DPP4ENPEP | |
| SCHEMBL29378939 | 0.75 | PDCD1LG2 (0.40) | ALDH1A1MAPTPTGS1DPP4ENPEP | |
| SCHEMBL26781562 | 0.75 | PDCD1LG2 (0.35) | DPP4ENPEPPDCD1LG2CD274MME | |
| SCHEMBL5592262 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2019-03-07 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | ALDH1A1 3923/4885MAPT 405/4885PTGS1 3605/4885 |
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | ALDH1A1 3923/4885MAPT 405/4885PTGS1 3605/4885 |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | DNPEP, VIP, PTMS | ALDH1A1 4177/4885MAPT 727/4885PTGS1 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.