Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27710988 | 0.86 | KCNH2 (0.46) | KCNH2CYP19A1HDAC1 | |
| SCHEMBL7026717 | 0.85 | CYP19A1 (0.35) | CYP19A1HDAC1TSHR | |
| SCHEMBL8664135 | 0.84 | KCNH2 (0.48) | KCNH2CYP19A1HDAC1 | |
| SCHEMBL24618609 | 0.83 | KCNH2 (0.38) | KCNH2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL294058 | 0.83 | KCNH2 (0.35) | KCNH2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| Ammonia Solution, Strong SCHEMBL28056861 | 0.83 | CYP19A1 (0.34) | CYP19A1HDAC1 | |
| SCHEMBL20464448 | 0.83 | ALDH1A1 (0.37) | KCNH2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| Bromide SCHEMBL28241981 | 0.82 | ALDH1A1 (0.36) | KCNH2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL294967 | 0.80 | HDAC1 (0.36) | KCNH2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL23542447 | 0.80 | KCNH2 (0.36) | KCNH2ALDH1A1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055298-B1 | MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE | SUTRO BIOPHARMA INC (US) | 2020-04-29 | — | — | EP | disclosed |