Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CCND3 | P30281 | 2/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 5/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23081098 | 0.88 | LCK (0.59) | CDK4CCNA2CDK2CCND3CDK6 | |
| SCHEMBL21946319 | 0.88 | BTK (0.59) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL21855202 | 0.88 | BTK (0.59) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL21855214 | 0.82 | JAK3 (0.70) | BTKLCKJAK3EGFR | |
| SCHEMBL21946753 | 0.82 | CKS1B (0.48) | CCNA2CDK2CCND3CDK6BTK | |
| SCHEMBL18884637 | 0.81 | BTK (0.64) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL29264652 | 0.81 | JAK3 (0.53) | BTKLCKJAK3EGFR | |
| SCHEMBL21947866 | 0.78 | BTK (0.55) | BTKLCKJAK3EGFR | |
| SCHEMBL21946750 | 0.77 | BTK (0.40) | BTKLCKJAK3EGFR | |
| SCHEMBL25604897 | 0.77 | BTK (0.60) | BTKLCKJAK3EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |