Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.59 |
| ▸ | LCK | P06239 | 9/20 | 0.59 |
| ▸ | JAK3 | P52333 | 14/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855202 | 1.00 | BTK (0.59) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL18884637 | 0.94 | BTK (0.64) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL18884550 | 0.88 | JAK3 (0.62) | BTKLCKJAK3SYK | |
| SCHEMBL21947866 | 0.88 | BTK (0.55) | BTKLCKJAK3EGFR | |
| SCHEMBL21946745 | 0.88 | CDK4 (0.49) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL25605387 | 0.88 | BTK (0.59) | BTKLCKJAK3EGFR | |
| SCHEMBL18296155 | 0.88 | LCK (0.73) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL18884392 | 0.87 | JAK3 (0.69) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL25605382 | 0.87 | BTK (0.62) | BTKLCKJAK3EGFRSYK | |
| SCHEMBL21947880 | 0.86 | BTK (0.57) | BTKLCKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |