Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.54 |
| ▸ | BTK | Q06187 | 11/20 | 0.54 |
| ▸ | JAK3 | P52333 | 18/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855164 | 0.91 | LCK (0.59) | LCKBTKJAK3EGFR | |
| SCHEMBL21946318 | 0.91 | LCK (0.59) | LCKBTKJAK3EGFR | |
| SCHEMBL24927490 | 0.91 | LCK (0.59) | LCKBTKJAK3EGFR | |
| SCHEMBL31039906 | 0.91 | LCK (0.59) | LCKBTKJAK3EGFR | |
| SCHEMBL21946354 | 0.87 | JAK3 (0.56) | LCKBTKJAK3EGFR | |
| SCHEMBL21855407 | 0.85 | JAK3 (0.67) | LCKBTKJAK3EGFR | |
| SCHEMBL21946347 | 0.84 | JAK3 (0.56) | LCKBTKJAK3EGFR | |
| SCHEMBL31039885 | 0.84 | BTK (0.52) | LCKBTKJAK3EGFR | |
| SCHEMBL21946887 | 0.84 | JAK3 (0.64) | LCKBTKJAK3EGFR | |
| SCHEMBL18884637 | 0.84 | BTK (0.64) | LCKBTKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |