Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569267 | 1.00 | GSTO1 (0.51) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21545349 | 0.92 | HTR2B (0.54) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21545661 | 0.92 | HTR2B (0.56) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21545347 | 0.92 | HTR2B (0.54) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21545662 | 0.92 | HTR2B (0.56) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21569361 | 0.91 | TP53 (0.56) | HTR2BMAPTTP53LMNAMEN1 | |
| SCHEMBL21947439 | 0.91 | TP53 (0.56) | HTR2BMAPTTP53LMNAMEN1 | |
| SCHEMBL21545652 | 0.90 | HTR2B (0.46) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21947500 | 0.89 | MAPT (0.56) | GSTO1HTR2BMAPTTP53LMNA | |
| SCHEMBL21545552 | 0.89 | MAPT (0.53) | HTR2BMAPTTP53LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654837-B2 | Sulphamoylaryl derivatives and use thereof as medicaments for the treatment of liver fibrosis | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654837-B2 | Sulphamoylaryl derivatives and use thereof as medicaments for the treatment of liver fibrosis | HTR2B, HTR3B, HTR1A | GSTO1 1258/4885HTR2B 1/4885MAPT 4615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.