Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 9/20 | 0.58 |
| ▸ | GNAI1 | P63096 | 9/20 | 0.58 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21947715 | 0.95 | GNAI3 (0.66) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL7485454 | 0.83 | GNAI3 (0.60) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL9062091 | 0.83 | NPC1 (0.81) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL673399 | 0.82 | — | — | |
| SCHEMBL9224930 | 0.81 | GNAI3 (0.84) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL27429180 | 0.81 | GNAI3 (0.60) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL12841072 | 0.80 | EPHX2 (0.51) | NPC1ALDH1A1 | |
| SCHEMBL22874721 | 0.80 | GNAI3 (0.57) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL27429182 | 0.80 | GNAI3 (0.57) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL13773022 | 0.80 | GNAI3 (0.68) | GNAI3GNAI1GNAO1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |