Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 10/20 | 0.84 |
| ▸ | GNAI1 | P63096 | 10/20 | 0.84 |
| ▸ | GNAO1 | P09471 | 9/20 | 0.84 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459406 | 0.89 | GNAI3 (0.69) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL1562717 | 0.89 | GNAI3 (0.72) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL21886614 | 0.84 | GNAI3 (0.77) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL7485454 | 0.83 | GNAI3 (0.60) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL9062091 | 0.83 | NPC1 (0.81) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL25033860 | 0.83 | GNAI3 (0.65) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL10239178 | 0.83 | GNAI3 (0.65) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL5392989 | 0.83 | GNAI3 (0.79) | GNAI3GNAI1GNAO1L3MBTL1NPC1 | |
| SCHEMBL673399 | 0.82 | — | — | |
| SCHEMBL21947693 | 0.81 | GNAI3 (0.58) | GNAI3GNAI1GNAO1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| US-5378691-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | disclosed |