⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21238672 | 1.00 | — | — | |
| SCHEMBL10177657 | 1.00 | — | — | |
| SCHEMBL19928452 | 0.86 | HSD11B1 (0.31) | — | |
| SCHEMBL14330447 | 0.86 | — | — | |
| SCHEMBL19928454 | 0.84 | DPP4 (0.30) | — | |
| SCHEMBL19965830 | 0.83 | — | — | |
| SCHEMBL20715709 | 0.83 | SHBG (0.33) | — | |
| SCHEMBL19928466 | 0.83 | — | — | |
| SCHEMBL24255705 | 0.80 | SHBG (0.34) | — | |
| SCHEMBL24255822 | 0.80 | SHBG (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174264-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-20200231594-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-07-23 | — | — | US | disclosed |
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |