Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21961727 | 0.77 | IDH1 (0.38) | IDH1 | |
| SCHEMBL21948536 | 0.77 | IDH1 (0.38) | IDH1 | |
| SCHEMBL35212475 | 0.74 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL31437285 | 0.74 | UTS2R (0.43) | MAPK1 | |
| SCHEMBL26674860 | 0.74 | UTS2R (0.43) | MAPK1 | |
| SCHEMBL21948540 | 0.74 | IDH1 (0.36) | IDH1 | |
| SCHEMBL31441739 | 0.71 | KDM4E (0.47) | TDP1 | |
| SCHEMBL15206197 | 0.68 | MERTK (0.45) | AXL | |
| SCHEMBL360202 | 0.65 | — | — | |
| SCHEMBL7466779 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |