Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12914173 | 0.81 | MC4R (0.30) | ALOX5APFEN1CA1CA2TRPA1 | |
| SCHEMBL21964686 | 0.70 | USP1 (0.33) | — | |
| SCHEMBL21764022 | 0.68 | FAAH (0.40) | CA1CA2CA12CA9FAAH | |
| SCHEMBL23132917 | 0.67 | NR1I2 (0.33) | CA1CA2FAAHLMNACYP1A2 | |
| SCHEMBL18438723 | 0.66 | — | — | |
| SCHEMBL18729638 | 0.63 | CYP1A2 (0.46) | ALOX5APFEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL13863865 | 0.63 | BRD4 (0.51) | TSHRHTR2CPIP4K2C | |
| SCHEMBL23879670 | 0.63 | CYP1A2 (0.46) | ALOX5APFEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL2737326 | 0.63 | NR1I2 (0.39) | CA1CA2FAAHLMNACYP1A2 | |
| SCHEMBL8190241 | 0.63 | CLK4 (0.49) | LMNACYP1A2CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |