Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | ROS1 | P08922 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | PYGM | P11217 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21949125 | 0.91 | PYGM (0.41) | SYKRETROS1FLT3EML4 | |
| SCHEMBL21949453 | 0.91 | KMT2A (0.40) | HTTL3MBTL1SYKALDH1A1LMNA | |
| SCHEMBL21949422 | 0.90 | MAPK10 (0.41) | SYKRETROS1FLT3EML4 | |
| SCHEMBL21949415 | 0.88 | PYGM (0.43) | HTTLMNAPYGMIRAK4NPC1 | |
| SCHEMBL21949426 | 0.86 | MAPK9 (0.41) | JAK3ALDH1A1SMN1; SMN2ALKBTK | |
| SCHEMBL21949405 | 0.81 | PYGM (0.44) | FLT3PYGMEGFRNPC1RAB9A | |
| SCHEMBL21949448 | 0.80 | SRC (0.41) | SYKJAK3JAK2EGFRIRAK4 | |
| SCHEMBL21949454 | 0.80 | IRAK4 (0.41) | SYKFLT3BTKPYGMMAPK10 | |
| SCHEMBL21949142 | 0.80 | SYK (0.40) | SYKJAK3ALDH1A1JAK2BTK | |
| SCHEMBL21949135 | 0.79 | PYGM (0.41) | SYKFLT3PYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640247-B1 | SYK INHIBITOR AND USE METHOD THEREFOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-3640247-A1 | SYK INHIBITOR AND USE METHOD THEREFOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-04-22 | — | — | EP | disclosed |