Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.36 |
| ▸ | STAT6 | P42226 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21949393 | 0.89 | ZAP70 (0.39) | FGFR1SRCMAPTMAPK1TP53 | |
| SCHEMBL21949415 | 0.85 | PYGM (0.43) | FGFR1SRCMAPTMAPK1TP53 | |
| SCHEMBL21949454 | 0.83 | IRAK4 (0.41) | SYKFGFR1SRCMAPTMAPK1 | |
| SCHEMBL21949426 | 0.80 | MAPK9 (0.41) | MAPTZAP70KDM4EALDH1A1TDP1 | |
| SCHEMBL21949412 | 0.80 | HTT (0.42) | SYKALDH1A1BTKJAK3JAK2 | |
| SCHEMBL21949865 | 0.78 | FGFR1 (0.44) | FGFR1SRCMAPTMAPK1TP53 | |
| SCHEMBL21949405 | 0.78 | PYGM (0.44) | FGFR1SRCEGFR | |
| SCHEMBL21949139 | 0.77 | SYK (0.39) | SYKSRCMAPTMAPK1MAPKAPK5 | |
| SCHEMBL21949135 | 0.76 | PYGM (0.41) | SYK | |
| SCHEMBL21949125 | 0.75 | PYGM (0.41) | SYKMAPTMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640247-B1 | SYK INHIBITOR AND USE METHOD THEREFOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-3640247-A1 | SYK INHIBITOR AND USE METHOD THEREFOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-04-22 | — | — | EP | disclosed |