Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2D3 | P61077 | 2/20 | 0.60 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TAS2R46 | P59540 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20642955 | 1.00 | UBE2D3 (0.60) | UBE2D3GBA1ESR1SMN1; SMN2PKM | |
| SCHEMBL20642959 | 0.81 | UBE2D3 (0.55) | UBE2D3PKMALDH1A1MAPTKMT2A | |
| SCHEMBL20642970 | 0.78 | UBE2D3 (0.75) | UBE2D3SMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL22009589 | 0.78 | UBE2D3 (0.69) | UBE2D3PKMKMT2ATAS2R46MEN1 | |
| SCHEMBL20642945 | 0.78 | UBE2D3 (0.85) | UBE2D3PKMKMT2ATAS2R46MEN1 | |
| SCHEMBL22009464 | 0.78 | UBE2D3 (0.75) | UBE2D3SMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL20642949 | 0.78 | UBE2D3 (0.69) | UBE2D3PKMKMT2ATAS2R46MEN1 | |
| SCHEMBL22009588 | 0.78 | UBE2D3 (0.69) | UBE2D3PKMKMT2ATAS2R46MEN1 | |
| SCHEMBL22155341 | 0.78 | UBE2D3 (0.68) | UBE2D3PKMKMT2ATAS2R46MEN1 | |
| SCHEMBL23662701 | 0.77 | TAS2R46 (0.38) | UBE2D3GBA1ESR1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653614-B1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS | SHANGHAI QINGDONG BIOTECHNOLOGY CO LTD (CN) | 2022-04-20 | — | — | EP | claimed |
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2021-06-15 | — | — | US | claimed |
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | Shanghai Qingdong Biotechnology Co., Ltd. (CN) | 2020-06-25 | — | — | US | claimed |
| EP-3653614-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2020-05-20 | — | — | EP | claimed |
| EP-3653614-B1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS | SHANGHAI QINGDONG BIOTECHNOLOGY CO LTD (CN) | 2022-04-20 | — | — | EP | disclosed |
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | Shanghai Qingdong Biotechnology Co., Ltd. (CN) | 2020-06-25 | — | — | US | disclosed |
| EP-3653614-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2020-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | NR0B1, FOXM1, CYP1A1 | UBE2D3 2113/4885GBA1 4706/4885ESR1 1356/4885 |
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | NR0B1, FOXM1, CYP1A1 | UBE2D3 2113/4885GBA1 4706/4885ESR1 1356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.