Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 16/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21953819 | 0.80 | CYSLTR2 (0.42) | SYKPDK2 | |
| SCHEMBL21953511 | 0.79 | SYK (0.38) | SYK | |
| SCHEMBL1682805 | 0.72 | PTK2 (0.45) | SYK | |
| SCHEMBL563558 | 0.68 | GAA (0.52) | PDK2 | |
| SCHEMBL28370055 | 0.67 | EP300 (0.52) | EP300 | |
| SCHEMBL28373866 | 0.67 | EP300 (0.52) | EP300 | |
| SCHEMBL13434311 | 0.66 | LMNA (0.47) | EP300 | |
| SCHEMBL415823 | 0.64 | TNF (0.46) | EP300 | |
| SCHEMBL28373514 | 0.63 | JAK2 (0.75) | — | |
| SCHEMBL31141593 | 0.62 | ALOX5 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020085742-A1 | HETEROAROMATIC MACROCYCLIC DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2020-04-30 | — | — | WO | disclosed |