Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OAT | P04181 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2193929 | 0.72 | OAT (0.34) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL6566527 | 0.67 | GABRR1 (0.47) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL22618120 | 0.67 | GABRR1 (0.47) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL6566521 | 0.67 | GABRR1 (0.47) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL3872776 | 0.64 | GABRR1 (0.44) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL2832851 | 0.64 | GABRR1 (0.44) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL27231957 | 0.63 | ABAT (0.42) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL27224967 | 0.63 | ABAT (0.42) | OATGABRR1ABATTSHRMAPK1 | |
| SCHEMBL9161010 | 0.63 | TSHR (0.40) | GABRR1TSHRMAPK1HSD17B10TDP1 | |
| SCHEMBL337018 | 0.61 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791808-B1 | PROCESS FOR THE PREPARATION OF 4,5-DIAMINO SHIKIMICACID | HOFFMANN LA ROCHE (CH) | 2010-07-14 | — | — | EP | claimed |
| EP-2193116-A2 | PROCESS FROM SHIKIMIC ACID TO OSELTAMIVIR PHOSPHATE | F. Hoffmann-Roche AG (CH) | 2010-06-09 | — | — | EP | claimed |
| US-7514580-B2 | Process for the preparation of 4,5-diamino shikimic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-04-07 | — | — | US | claimed |
| WO-2009037137-A2 | PROCESS FROM SHIKIMIC ACID TO OSELTAMIVIR PHOSPHATE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-26 | — | — | WO | claimed |
| EP-1791808-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIAMINO SHIKIMICACID | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-06 | — | — | EP | claimed |
| WO-2006024436-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIAMINO SHIKIMICACID | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-09 | — | — | WO | claimed |
| US-20060047002-A1 | Process for the preparation of 4,5-diamino shikimic acid derivatives | HOFFMANN-LA ROCHE INC. | 2006-03-02 | — | — | US | claimed |
| US-7977077-B2 | Synthesis of intermediates of oseltamivir carboxylates | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2011-07-12 | — | — | US | disclosed |
| CN-101010289-B | Method for preparing 4, 5-diamino shikimic acid | HOFFMANN LA ROCHE | 2011-05-25 | — | — | CN | disclosed |
| EP-1791808-B1 | PROCESS FOR THE PREPARATION OF 4,5-DIAMINO SHIKIMICACID | HOFFMANN LA ROCHE (CH) | 2010-07-14 | — | — | EP | disclosed |
| US-7514580-B2 | Process for the preparation of 4,5-diamino shikimic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070190621-A1 | Synthesis of oseltamivir carboxylates | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-08-16 | — | — | US | disclosed |
| CN-101010289-A | Method for preparing 4, 5-diamino shikimic acid | HOFFMANN LA ROCHE (CH) | 2007-08-01 | — | — | CN | disclosed |
| EP-1791808-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIAMINO SHIKIMICACID | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006024436-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIAMINO SHIKIMICACID | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-09 | — | — | WO | disclosed |
| US-20060047002-A1 | Process for the preparation of 4,5-diamino shikimic acid derivatives | HOFFMANN-LA ROCHE INC. | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060047002-A1 | Process for the preparation of 4,5-diamino shikimic acid derivatives | NEU4, NEU1, NEU3 | OAT 1892/4885GABRR1 1836/4885ABAT 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.