Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24780661 | 0.81 | LMNA (0.39) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL8091807 | 0.80 | HRH3 (0.43) | HRH3LMNALTB4RLTB4R2 | |
| SCHEMBL8094726 | 0.80 | HRH3 (0.43) | HRH3LMNALTB4RLTB4R2 | |
| SCHEMBL16269835 | 0.80 | HRH3 (0.43) | HRH3LMNALTB4RLTB4R2 | |
| SCHEMBL25112109 | 0.75 | HRH4 (0.41) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL12090211 | 0.73 | MAP4K4 (0.49) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL9965979 | 0.73 | LMNA (0.48) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL8302404 | 0.71 | KDM4E (0.50) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL12090380 | 0.71 | KCNH2 (0.53) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL25839727 | 0.71 | HRH3 (0.46) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |