Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26124247 | 0.83 | TDP1 (0.40) | GAAKMT2AMEN1TDP1POLB | |
| SCHEMBL21961361 | 0.78 | PTGS2 (0.39) | SMN1; SMN2 | |
| SCHEMBL27002716 | 0.78 | CA1 (0.34) | GAAKMT2AMEN1TDP1CA12 | |
| SCHEMBL13764827 | 0.76 | GAA (0.45) | GAAKMT2AMEN1TDP1POLB | |
| SCHEMBL868203 | 0.76 | GAA (0.42) | GAAKMT2AMEN1TDP1POLB | |
| SCHEMBL868808 | 0.76 | MEN1 (0.42) | GAAKMT2AMEN1TDP1POLB | |
| SCHEMBL27849207 | 0.73 | GAA (0.40) | GAAKMT2AMEN1TDP1POLB | |
| SCHEMBL23880174 | 0.73 | L3MBTL1 (0.39) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL23248497 | 0.72 | MEN1 (0.36) | GAAKMT2AMEN1TDP1POLB | |
| SCHEMBL5410258 | 0.72 | GAA (0.48) | GAAKMT2AMEN1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |