Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21961391 | 0.77 | HPGDS (0.44) | HPGDSCDK2GSK3BCCNA2GSK3A | |
| SCHEMBL14387558 | 0.66 | — | — | |
| SCHEMBL21849265 | 0.65 | HPGDS (0.40) | HPGDSCDK2CCNA2MAPK8MAPK9 | |
| SCHEMBL21964551 | 0.65 | CDK1 (0.33) | CDK2CCNA2 | |
| SCHEMBL27919806 | 0.64 | KDM4E (0.40) | — | |
| SCHEMBL27674559 | 0.63 | CCNA2 (0.52) | CDK2CCNA2 | |
| SCHEMBL23344298 | 0.62 | GAA (0.41) | HPGDSACVR1 | |
| SCHEMBL27799858 | 0.61 | OPRL1 (0.42) | — | |
| SCHEMBL21816205 | 0.60 | HCAR2 (0.43) | HPGDSMAPK8MAPK9MAPK10CCR5 | |
| SCHEMBL27849851 | 0.59 | MKNK1 (0.46) | HPGDSCDK2GSK3BCCNA2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |