Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | IL2 | P60568 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18892042 | 0.77 | MAP4K1 (0.47) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL21961971 | 0.77 | MAPK1 (0.42) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL1487564 | 0.75 | MAP4K1 (0.47) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL21557641 | 0.73 | MAPK1 (0.48) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL1713730 | 0.72 | MAPK1 (0.45) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL20504119 | 0.71 | MAPK1 (0.51) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL31235685 | 0.69 | MAPK1 (0.59) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL1487526 | 0.69 | LRRK2 (0.59) | MAP4K1IL2MAPK1CLK1DYRK1A | |
| SCHEMBL26912252 | 0.69 | HSD11B1 (0.50) | MAP4K1IL2CLK1DYRK1ARPS6KA3 | |
| SCHEMBL25857010 | 0.68 | MAPK1 (0.46) | MAP4K1IL2MAPK1CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12428416-B2 | ERK inhibitors and uses thereof | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2025-09-30 | — | — | US | disclosed |
| US-20220002294-A1 | ERK INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-01-06 | — | — | US | disclosed |
| EP-3880677-A1 | ERK INHIBITORS AND USES THEREOF | California Institute of Technology (US) | 2021-09-22 | — | — | EP | disclosed |
| CN-113423707-A | ERK inhibitors and uses thereof | 加利福尼亚技术学院 | 2021-09-21 | — | — | CN | disclosed |
| WO-2020102686-A1 | ERK INHIBITORS AND USES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2020-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002294-A1 | ERK INHIBITORS AND USES THEREOF | MAPKAPK2, MAPK3, MAP4K2 | MAP4K1 12/4885IL2 3843/4885MAPK1 11/4885 |
| US-12428416-B2 | ERK inhibitors and uses thereof | MAPKAPK2, MAPK3, MAP4K2 | MAP4K1 12/4885IL2 3843/4885MAPK1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.